Cook broccoli according to package directions. Drain and slice lengthwise.
Spread bread with cream cheese and mustard. Top 4 slices of bread with cheese, broccoli, ham and remaining slices of bread.
Spray a preheated Panini grill with cooking spray. Place sandwiches on grill; spray tops of sandwiches with additional cooking spray. Grill until bread is golden brown and cheese is melted (about 5 minutes).